Stephen Dilly, MBBS, PhD
Stephen Dilly was appointed Chairman of the DNAtrix Board of Directors in July 2019. Dr. Dilly also serves as Chairman of Cognoa, a pediatric behavioral health company, on the Boards of Sangamo Therapeutics and Adjuvance Technologies, and on the Industry Advisory Board of Longitude Ventures. From April 2013 to June 2018, Stephen served as Chief Executive Officer and Board Member of Aimmune Therapeutics and currently serves as Special Advisor on Clinical and Regulatory affairs. Prior to that, Dr. Dilly was successively CEO and Board Member of PhotoThera, Inc., a medical device company with a product in Phase III clinical trials for the treatment of ischemic stroke, and APT Pharmaceuticals, a therapeutics company with a product in Phase III for lung transplant. From 2003 to 2006, he served as Chief Medical Officer and Senior Vice President of Development of Chiron BioPharma, a biotechnology company that was acquired by Novartis International AG. From 1998 to 2003, Stephen held positions of Vice President of Development Sciences and Vice President of Medical Affairs at Genentech. Earlier in his career, he held various management positions with SmithKline Beecham, most recently as Vice President of Clinical Neuroscience. Dr. Dilly has been closely associated with the development and launch of marketed drugs for many therapeutic areas, including Kytril, Paxil, Kredex, Requip, TNKase, Xolair, Avastin, Raptiva, Tarceva, Lucentis and Cubicin. In 1982, Dr. Dilly earned his M.B.B.S., the equivalent of an M.D. in the U.S., from the University of London in the U.K. and received his Ph.D. in Cardiac Physiology from University of London in 1988.
Chief Executive Officer, dnatrix
Jeff Knapp has over 30 years of experience in the pharmaceutical industry, including 20 in executive management. He has developed and executed strategies supporting clinical development, regulatory approval, and commercial launch of multiple products across a diverse array of therapeutic areas. Prior to joining DNAtrix, Jeff served as Chief Operating Officer at Aimmune Therapeutics where he was responsible for preparing the company’s first asset, AR101, for approval and commercial launch in the US & EU as a treatment for children and adolescents with peanut allergies. Before joining Aimmune, Jeff served as Chief Operating Officer at Adamas Pharmaceuticals. While working with Adamas, Jeff established the preliminary commercial and manufacturing infrastructure as the company moved from a privately held Phase 2 company to a publicly-traded Phase 3 / pre-commercial company and supported the company’s successful Initial Public Offering in April 2014. Jeff also served as Chief Commercial Officer at Affymax, where he developed the strategy and led the build out of the commercial organization leading to the successful 2012 launch of the company’s lead compound, OMONTYS® (peginesatide), for the treatment of anemia in patients with end-stage renal disease. Earlier in his career, Jeff held several senior positions in Sales and Marketing, including Senior Vice President and Vice President, at companies such as Abgenix (acquired by Amgen in April 2006), Pharmion Corporation, EMD Pharmaceuticals (a division of Merck KGaA), and the Oncology Division of Eli Lilly and Schering-Plough Corporation. Jeff received a BA in Biology with a Minor in Business Administration from Wittenberg University.
Isaac Cheng, MD
Dr. Cheng joined Morningside in 2006 and focuses on biopharmaceutical and healthcare investments. He is currently a director of Liquidia Technologies, Cognoa, K-Gen, Artugen Therapeutics, Cognito Therapeutics, Amylyx Pharmaceuticals, NuCana PLC (NASDAQ:NCNA) and Alms Therapeutics. Previously he was a board member of Advanced Cell Diagnostics (sold to Bio-Techne). Prior to joining Morningside, Dr. Cheng was Director of Research and Development at Serica Technologies, a Morningside portfolio company which was sold to Allergan. In addition, Dr. Cheng was previously an Associate Director at Novartis Pharmaceuticals in Clinical Development and Medical Affairs. Dr. Cheng received his M.D. from Tufts University School of Medicine. He is the recipient of numerous honors and awards including the Howard Hughes Medical Institute Research Fellowship, which supported his research under Dr. Rudy Tanzi at Massachusetts General Hospital / Harvard Medical School.
Frank McCormick, PhD, FRS
Professor, University of California San Francisco
Frank McCormick, PhD, FRS, is Professor Emeritus of the UCSF Helen Diller Family Comprehensive Cancer Center. Prior to joining the UCSF faculty, Dr. McCormick pursued cancer-related work with several Bay Area biotechnology firms and held senior research positions with Cetus Corporation and Chiron Corporation. In 1992 he founded Onyx Pharmaceuticals, a company dedicated to developing new cancer therapies, and served as its Chief Scientific Officer until 1996. His group discovered and co-developed sorafenib and palbociclib, and pioneered cancer therapy using oncolytic viruses. Dr. McCormick's current research interests center on the fundamental differences between normal and cancer cells that can allow the discovery of novel therapeutic strategies.
Dr. McCormick holds the David A. Wood Chair of Tumor Biology and Cancer Research at UCSF. Dr. McCormick is the author of over 285 scientific publications and holds 20 issued patents. More recently, he has taken a leadership role at the Frederick National Lab for Cancer Research, overseeing an NCI supported national effort to develop therapies against Ras-driven cancers. These cancers include most pancreatic cancers, and many colorectal and lung cancers, and are amongst the most difficult cancers to treat.
Drew Pardoll, MD, PhD
Professor, Johns Hopkins University of Medicine
Drew Pardoll is Seraph Professor of Oncology, Medicine, Pathology and Molecular Biology and Genetics at the Johns Hopkins University of Medicine. He is Co-Director of the Cancer Immunology Program in the Sydney Kimmel Comprehensive Cancer Center. Dr. Pardoll completed his MD, PhD, Medical Residency and Oncology Fellowship at Johns Hopkins University. Dr. Pardoll has published over 200 papers as well as over 20 book chapters on the subject of T cell immunology and cancer vaccines. He has served on the editorial board of the Journal of the National Cancer Institute and Cancer Cell, and has served as a member of scientific advisory boards for the Cancer Research Institute, the University of Pennsylvania Human Gene Therapy Gene Institute, Biologic Resources Branch of the National Cancer Institute, Harvard-Dana Farber Cancer Center, Aduro Biotech, Cerus Corporation, Global Medical Products Corporation, Genencor Corporation, Cell Genesys Corporation, Mojave Therapeutics, the American Association of Clinical Oncology and the American Association of Cancer Research. Dr. Pardoll has made a number of basic advances in cellular immunology, including the discovery of gamma-delta T cells, NKT cells and interferon-producing killer dendritic cells. Over the past two decades, Dr. Pardoll has studied molecular aspects of dendritic cell biology and immune regulation, particularly related to mechanisms by which cancer cells evade elimination by the immune system. He is an inventor of a number of immunotherapies, including GVAX cancer vaccines and Listeria monocytogenes-based cancer vaccines.
Dan Watkins, PhD
Partner, Mercury Fund
Dan Watkins co-founded Mercury Fund where he leads the Sciences team. He focuses on both Physical and Life Science startups, many at the formation or university spinoff stage. Dr. Watkins has served in a number of operational roles including initial CEO of DNAtrix and Nanospectra Biosciences, both oncology companies. Prior to Mercury, he has been Vice President at a boutique investment banking firm and Worldwide Manager of Operations Control Systems for Scientific Software Intercomp. Dr. Watkins serves on the board of directors of a number of life sciences companies including: DNAtrix, GlycosBio (industrial biotechnology), Swift Biosciences (next generation sequencing), Sinopsys (medical device) and Resonant (novel antibody discovery). Dr. Watkins received his BS from Rice University and his MS and PhD from Carnegie Mellon University, all in Materials Science. Dan serves on the advisory boards of Northwestern University’s Innovation and New Ventures Office (INVO), the University of Michigan’s Venture Center Council, and BioHouston. He is also the co-founder of the Rice Alliance for Technology and Entrepreneurship at Rice University.