Oncolytic Adenovirus Armed with T-Cell Stimulator
DNAtrix’s next generation virus, DNX-2440, is engineered to express OX40 ligand (OX40L) in the local tumor environment to enhance immune-mediated cell killing. OX40 is a member of the tumor necrosis factor receptor superfamily, and interactions between OX40 and OX40L act as co-stimulatory signals for T-cell activation. Extensive preclinical data show that DNX-2440 triggers an antitumor immune response, tumor-specific immune memory, and an abscopal effect (shrinking of an untreated tumor distant from the treated tumor) leading to prolonged survival in difficult-to-treat models of cancer, including gliomas, melanomas, breast, and lung cancers. DNX-2440 recently entered the clinic to treat cancers with high unmet medical need.